DENARASE®

For Viral Vector Production!

Enzymatic DNA Removal in Bioprocessing

DENARASE® is a genetically engineered endonuclease from Serratia marcescens used as a DNA eraser in purification processes of biological molecules. The enzyme cleaves all forms of DNA and RNA into smaller nucleotides of around 5-8 base pairs.

The enzyme is active in a broad range of conditions and is free of proteolytic activity. This makes the enzyme especially useful for applications with challenging DNA contents such as lysed host cells in viral vector manufacturing processes.

Because of its high efficacy, enzymatic digestion is a preferred method for reducing DNA levels well below the limits for biologicals set by the authorities.

The patented production process uses a Bacillus sp. production host. The gram-positive, endotoxine-free strain is highly productive and mitigates the risk of endotoxins in the final product. DENARASE has a purity of ≥ 99 % and is manufactured in full compliance with GMP requirements using only raw materials of non-animal origin and without the use of antibiotics.

DENARASE is used especially in the field of:

  • Gene Therapy manufacturing
  • Cell Therapy manufacturing
  • Viral Vector purification
  • Vaccine production

Multiple sizes to fit your requirements

DENARASE,100 kU
DENARASE, 500 kU
DENARASE, 1 MU
DENARASE, 5 MU
Free sample
ELISA Kit

DENARASE®️ 100 kU

$ 390.00
Buy now

For process development of biologicals such as viral vectors and vaccines. The enzyme reduces all forms of DNA and RNA and enables a simpler, more efficient downstream process.

Purity: ≥ 99%​
Activity:
> 250 U/µl​
Formulation:
buffered aqueous glycerol solution
Storage Temperature:
-20°C
Estimated Delivery time:
1-2 weeks (depending on region)

  • Produced under GMP conditions and filled under ISO9001
  • Manufacturing process free of materials with TSE/BSE risk and of raw materials from animal origin
  • Depending on your application 10 – 60 U/ml is needed ​
  • net price excluding VAT and shipment costs

DENARASE®️ 500 kU

$ 1,200.00
Buy now

For process development of biologicals such as viral vectors and vaccines. The enzyme reduces all forms of DNA and RNA and enables a simpler, more efficient downstream process.

Purity: ≥ 99%​
Activity:
> 250 U/µl​
Formulation:
buffered aqueous glycerol solution
Storage Temperature:
-20°C
Estimated Delivery time:
1-2 weeks (depending on region)

  • Produced under GMP conditions and filled under ISO9001
  • Manufacturing process free of materials with TSE/BSE risk and of raw materials from animal origin
  • Depending on your application 10 – 60 U/ml is needed ​
  • net price excluding VAT and shipment costs

DENARASE®️ 1 MU

For GMP manufacturing of biologicals such as viral vectors and vaccines. The enzyme reduces all forms of DNA and RNA and enables a simpler, more efficient downstream process.

Purity: ≥ 99%​
Activity: > 250 U/µl​
Formulation:
buffered aqueous glycerol solution
Storage Temperature:
-20°C
Estimated Delivery time:
1-2 weeks (depending on region)

  • produced and filled under GMP conditions acc. to EU GMP regulation
  • Manufacturing process free of materials with TSE/BSE risk and of raw materials from animal origin
  • Depending on your application 10 – 60 U/ml is needed ​

DENARASE®️ 5 MU

For GMP manufacturing of biologicals such as viral vectors and vaccines. The enzyme reduces all forms of DNA and RNA and enables a simpler, more efficient downstream process.

Purity: ≥ 99%​
Activity: > 250 U/µl​
Formulation:
buffered aqueous glycerol solution
Storage Temperature:
-20°C
Estimated Delivery time:
1-2 weeks (depending on region)

  • produced and filled under GMP conditions acc. to EU GMP regulation
  • Manufacturing process free of materials with TSE/BSE risk and of raw materials from animal origin
  • Depending on your application 10 – 60 U/ml is needed ​

Free sample DENARASE 25 kU

For process development of biologicals such as viral vectors and vaccines. The enzyme reduces all forms of DNA and RNA and enables a simpler, more efficient downstream process.


Purity: ≥ 99%​
Activity:
> 250 U/µl​
Formulation:
buffered aqueous glycerol solution
Storage Temperature:
-20°C
Estimated Delivery time:
1-2 weeks (depending on region)

  • Produced under GMP conditions and filled under ISO9001
  • Manufacturing process free of materials with TSE/BSE risk and of raw materials from animal origin
  • Depending on your application 10 – 60 U/ml is needed ​
  • sample is shipped DAP (delivery at place)

DENARASE®️ ELISA Kit

$ 3,350.00
Buy now

For the quantitative analysis of residual Serratia marcescens endonucleases in process samples.

  • The kit consists of a pre-coated micro test plate and ready to use reagents. ​
  • The capacity of 1 kit is 480 measurements ​
  • Estimated Delivery time: 1-2 weeks (depending on region)​
  • net price excluding VAT and shipment costs

Not quite ready to buy yet?

  • Get your free sample DENARASE!

    New customers from the pharmaceutical industry can request a free 25 kU sample for first lab trials.

  • ELISA-Kit for analytical support

    For the quantitative analysis of endonucleases from Serratia marcescens a DENARASE ELISA detection kit is available.

    learn more

Get in touch!

Speak to a member of our expert team and learn more about our DENARASE products!

Qualified and used
by big pharma companies


  • „We have used DENARASE in our manufacturing production. It is good according to our test. We plan to use it in next valuable schedule.”

    US-Children Hospital, USA,
    Clinical Vector Core, Lead Scientist
  • „I tested the DENARASE yesterday and it was equally good as our standard in my setting. I will continue using it in variety of conditions that I normally use and I will most certainly be purchasing my future enzymes from you.”

    US University, USA,
    Scientist
  • „We are going to use DENARASE exclusively and no longer our usual nuclease. The product is excellent in performance and price.”

    US biopharmaceutical manufacturer, USA,
    Lab Manager Vector Production