DENARASE®

For Viral Vector Production

Vaccine Manufacturing

Vaccines play an important role in the health of the world population. Some of their distinctive features is that they need to be available in large quantities, often very quickly and at a very low cost per unit. This results in a complicated supply chain - even more so because high quality is at least as important as for other pharma products, since vaccines are preventive rather than curative products.

Enzymes such as DENARASE endonuclease can be of great benefit for vaccine purification since they are available in large quantities at the highest quality level. Enzymes do not interfere with other molecules, which makes the process of developing urgently needed vaccines much faster.

Vaccines are intended to activate the human immune system against threats such as unknown viruses. The vaccines can be an inactivated form of the whole virus, an attenuated virus, or a part of the virus (antigen). More modern approaches even use viral vectors or directly introduce DNA or RNA in the body to express antigens in cells.

Endonucleases are used in a range of vaccine purification applications with various expression systems. Examples of processes with DENARASE are:

  • Viral Vector Production, such as Adenoviruses and AAV’s
  • Viral Vaccines
  • Virus Like Particles

Treatment of cell lysates, before viral vector purification is one of the applications for which DENARASE is often used. High DNA concentrations originating from the host cell can form aggregates with the product and cell debris, which leads to reductions in capacity of purification equipment. Addition of DENARASE reduces the formation of aggregates, thus increasing the overall vaccine yield.

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  • Request your free sample!

    New customers from the pharmaceutical industry can request a free 25 kU sample for first lab trials. Please fill out the request form to get your free sample.

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Qualified and used
by big pharma companies


  • „We have used DENARASE in our manufacturing production. It is good according to our test. We plan to use it in next valuable schedule.”

    US-Children Hospital, USA,
    Clinical Vector Core, Lead Scientist
  • „I tested the DENARASE yesterday and it was equally good as our standard in my setting. I will continue using it in variety of conditions that I normally use and I will most certainly be purchasing my future enzymes from you.”

    US University, USA,
    Scientist
  • „We are going to use DENARASE exclusively and no longer our usual nuclease. The product is excellent in performance and price.”

    US biopharmaceutical manufacturer, USA,
    Lab Manager Vector Production