DENARASE® uses Mg2+ as a cofactor and a minimum amount is needed for enzyme activity. DENARASE® requires 1- 2 mM Mg2+ cations for optimal activity (see Fig. 3). A large excess of MgCl2 reduces activity (see Fig. 4).
Stability and Storage Conditions
DENARASE® is stable within the specification range at a storage temperature of -20 °C for a period of at least 24 months from the date of product release. Note: It is not recommended to store the product at -70 °C or below, since freezing the product will cause loss of activity.
DENARASE® is filled in non-pyrogenic, USP Class VI-compliant vials. The product vials are packed in polystyrene boxes and shipped under refrigerated conditions. Shipping temperature may differ from storage temperature without affecting product quality.
Please refer to the Validation Guide, which is available on request, for more information on the enzyme activity.